CANNABIS DOSING 101
CANNABIS DOSING 101 BY MARTIN A. LEE – Project CBD
High dose? Low dose? CBD? THC? Optimizing one’s therapeutic use of cannabis may entail some experimentation. In essence, the goal is to administer consistent, measurable doses of a CBD-rich cannabis remedy with as much THC as a person is comfortable with.
Cannabis can be effective therapeutically at a wide range of doses. There’s no standard dosage that’s right for everyone. Here are some do’s and don’ts for dosing cannabis:
- The successful use of cannabis as a medicine depends on managing its psychoactive properties. Many people enjoy the cannabis high; others do not. A person’s sensitivity to THC (“The High Causer”) is key to implementing an effective treatment regimen.
- One does not need to smoke marijuana or get high to benefit from medical cannabis.
- CBD is not psychoactive like THC. High doses of CBD-rich formulations are safe, well tolerated, and sometimes necessary.
- But high doses of CBD are not always more effective than lower doses. As little as 2.5 mg CBDcombined with a small amount of THC can have a therapeutic effect.
- Preclinical studies have shown that full-spectrum CBD-rich cannabis oil (with a small amount of THC) is efficacious at much lower doses and has a much wider therapeutic window than pure, pharmaceutical-grade CBD.
- Less is more: Cancer patients who received 21 mg/day of Sativex (a cannabis sublingual spray with roughly equal amounts of CBD and THC) experienced significant reductions in pain, more so than cancer patients who received 52 mg of Sativex, while those who were given 83 mg of Sativex reduced their pain no better than a placebo.
- Cautious titration is recommended when ingesting THC-rich cannabis products (with little CBD). Microdosing as little as 2.5 mg THC can provide symptom relief without making a person feel high. If well tolerated, consider increasing the amount of THC to a total of 15 mg divided equally throughout the day.
- Cumulative doses of THC exceeding 20-30 mg per day – or a single dose of 10 mg or more – may cause unwanted side effects.
- For cannabis-naïve patients, it may be best to start with low doses of a CBD-rich remedy with little THC and slowly increase the dosage – and, if necessary, the amount of THC – one step at a time. Take a few small doses over the course of the day, rather than one big dose.
Figuring out the optimal dose of cannabis may involve some trial and error. A balanced ratio of CBDand THC could have a greater therapeutic impact than either CBD or THC alone. Adjust the amount of CBD and THC until you find the sweet spot with the right combination of both compounds. In essence, the goal is to administer consistent, measurable doses of a CBD-rich cannabis remedy with as much THC as a person is comfortable with.